Long-Term Durability of Acoramidis Efficacy in Transthyretin Amyloid Cardiomyopathy: Open-Label Extension of the ATTRibute-CM Randomized Clinical Trial

Heart Failure

Sacubitril/Valsartan vs Enalapril in Heart Failure Due to Chagas Disease: An Open-Label, Multicenter Randomized Clinical Trial

JAMA

Lopes RD, Bocchi EA, Echeverría LE, Demacq C, de Barros E Silva PGM, Barbosa LM, Damiani L, Sayyed S, Yoshida LAF, Furtado RHM, Morillo CA, Kevorkian R, Ramires F, Bahit MC, Magaña A, Chávez-Mendoza A, Miguel da Silva AH, Coelho da Silva A, Freitas AF Jr, Romano AA, Parneix A, Segura A, França CCB, Botta CE, de Barros E, Perna ER, Montenegro E, Quiroz Diaz FR, Feitosa-Filho GS, Severini GV, Molina I, Miranda JDSS, Sala J, Kerr Saraiva JF, Carbajales J, Maia LN, Santana Passos LC, Simões MV, Moreira MDCV, Nunes MCP, Hernandes ME, Hominal M, Zarandon RS, Leon de la Fuente R, Aras R, Bazan SGZ, Luiz da Silva T Jr, Madrini V, de Oliveira WA Jr, Saporito WF, Gimpelewicz C, McMurray JJV, Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators

doi: 10.1001/jama.2025.19808

Heart, Artery and Coronary Diseases

Survival After Initial Stress Testing vs Anatomic Testing in Suspected Coronary Artery Disease: Long-Term Follow-Up of the PROMISE Randomized Clinical Trial

JAMA Cardiol

Douglas PS, Stebbins A, Foldyna B, Patel MR, Mark DB, Lu MT, Hoffmann U, Shah SH, Martinez B, Alhanti B, Pagidipati N

doi: 10.1001/jamacardio.2025.2882

Heart Failure

Long-Term Outcomes of Left Bundle-Branch Pacing vs Biventricular Pacing in Heart Failure: The HeartSync-LBBP Randomized Clinical Trial

JAMA Cardiol

Chen X, Liu X, Li R, Wang Z, Liang Y, Zhang L, Wang W, Bai J, Wang J, Qin S, Zhang W, Yao T, Huang D, Chen T, Zhao X, Liao D, Li J, Mao J, Chelu MG, Su Y, Ellenbogen KA, Ge J

doi: 10.1001/jamacardio.2026.0083

Heart, Artery and Coronary DiseasesTherapy and Intervention

Efficacy and Safety of Edoxaban in Anticoagulant Therapy Early After Surgical Bioprosthetic Valve Replacement: A Randomized Clinical Trial

Circ Cardiovasc Interv

Izumi C, Amano M, Yoshikawa Y, Fukushima S, Yaku H, Eishi K, Sakaguchi T, Ohno N, Hiraoka A, Okada K, Saiki Y, Miura T, Komiya T, Minami M, Yamamoto H, Omae K, ENBALV Trial Investigators

doi: 10.1161/CIRCINTERVENTIONS.124.015108

Atrial FibrillationThrombosis and Stroke

Left Atrial Appendage Closure versus Oral Anticoagulation for Stroke Prevention in Atrial Fibrillation: Long-Term Outcomes from Four Randomized Trials

Heart Rhythm

Kaisaier W, Xu Z, Guo L, Dong Y, Chen Y, Lip GYH, Zhu W

doi: 10.1016/j.hrthm.2025.07.051

Heart FailureFurther Publications

Efficacy and Tolerability of Finerenone According to the Use and Dosage of Diuretics: A Prespecified Analysis of the FINEARTS-HF Randomized Clinical Trial

JAMA Cardiol

Chimura M, Jhund PS, Henderson AD, Yang M, Claggett BL, Desai AS, Rohwedder K, Lage A, Scalise A, Mueller K, Schou M, Lam CSP, Senni M, Voors AA, Zannad F, Pitt B, Vaduganathan M, Solomon SD, McMurray JJV

doi: 10.1001/jamacardio.2025.2551

Hypertension

Efficacy of Tonlamarsen in Patients With Uncontrolled Hypertension: The KARDINAL Phase 2 Randomized Clinical Trial

J Am Coll Cardiol

Laffin LJ, Wang Q, Sarraju A, Touyz RM, Schlaich MP, Cohen DL, Mahfoud F, Mitchell LM, Mitchell J, Wolski K, Dennis P, Akere A, Li W, Chen G, Cohen YZ, Kim J, Cooper CG, Ramesan P, Edelberg JM, Nissen SE, KARDINAL Investigators

doi: 10.1016/j.jacc.2026.03.034

Further Publications

Detecting Transthyretin Cardiac Amyloidosis With Artificial Intelligence: A Nonrandomized Clinical Trial

JAMA Cardiol

Jain SS, Sun T, Pierson E, Roedan Oliver F, Malta P, Castillo M, Wan N, Alishetti S, Hartman H, Finer J, Brown KL, Ramlall V, Tatonetti N, Elhadad N, Rodriguez F, Witteles R, Goyal P, Homma S, Einstein AJ, Maurer MS, Elias P, Poterucha TJ

doi: 10.1001/jamacardio.2025.4591

Further Publications

Genetic Cascade Screening for Familial Hypercholesterolemia: A Randomized Clinical Trial

JAMA Netw Open

Nanchen D, Chaouch A, Scuderi R, Faivre V, von Känel T, Ehret G, Brun N, Sudano I, Rickli H, Girod G, Dettwiler AB, Krasieva K, Podmore C, Rodondi N, Moutzouri E, Ballhausen D, Del Giorno R, von Eckardstein A, Beer JH, Gallino A

doi: 10.1001/jamanetworkopen.2026.6100

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Sacubitril/Valsartan vs Enalapril in Heart Failure Due to Chagas Disease: An Open-Label, Multicenter Randomized Clinical Trial

Survival After Initial Stress Testing vs Anatomic Testing in Suspected Coronary Artery Disease: Long-Term Follow-Up of the PROMISE Randomized Clinical Trial

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