Standard-dose unfractionated heparin versus low-dose unfractionated heparin and low-molecular-weight heparin in extracorporeal life support (RATE): an open-label, randomised, non-inferiority trial

Atrial FibrillationHeart, Artery and Coronary Diseases

1-month versus 12-month dual antithrombotic therapy after percutaneous coronary intervention in patients with atrial fibrillation (OPTIMA-AF): a multicentre, open-label, hybrid non-inferiority and superiority, randomised, controlled trial

Lancet

Sotomi Y, Kozuma K, Higuchi Y, Nakazawa G, Morino Y, Ando K, Ako J, Tanabe K, Muramatsu T, Kobayashi K, Ichibori Y, Ishihara T, Hirooka K, Suwa S, Warisawa T, Naganuma T, Kikuchi A, Shutta R, Okamoto N, Tanabe Y, Okamura A, Kashiwabara K, Hikoso S, Sakata Y, OPTIMA-AF Investigators

doi: 10.1016/S0140-6736(26)00665-3

Heart, Artery and Coronary DiseasesTherapy and Intervention

Deferral of percutaneous coronary intervention in patients undergoing transcatheter aortic valve implantation (PRO-TAVI): an investigator-initiated, multicentre, open-label, non-inferiority, randomised controlled trial

Lancet

Delewi R, Aarts HM, Broeze GM, Hemelrijk KI, van Ginkel DJ, Versteeg GAA, Grundeken MJ, Claessen BEPM, Tonino PAL, Schotborgh CE, Meuwissen M, van Houwelingen GK, Wykrzykowska JJ, Amoroso G, Vossenberg TN, Vriesendorp PA, van Royen N, Ten Berg JM, Tijssen JGP, Voskuil M, PRO-TAVI trial investigators

doi: 10.1016/S0140-6736(26)00308-9

Heart, Artery and Coronary Diseases

Multivessel coronary artery bypass grafting via small thoracotomy versus sternotomy (MIST): an investigator-initiated, international, open-label, randomised controlled trial

Lancet

Ruel M, Nambala S, Guo MH, Verevkin A, Rabindranauth P, Kikuchi K, Davierwala PM, Lemma M, Ponnambalam M, Sheikh A, Black A, Borger MA, Whitlock RP, Zhang Y, Wells GA

doi: 10.1016/S0140-6736(26)01288-2

Hypertension

Low-Dose TEL/AML/CHTD SPC Versus Standard-Dose TEL in Hypertension: Phase III RCT

Hypertension

Ahn JC, Lee CW, Ahn JH, Lim KH, Sohn IS, Sung KC, Kim KH, Bae JH, Hong SP, Jang WY, Jo SH, Han SH, Kim JB, Lee CJ, Lee JH, Kim N, Cho EJ, Sung JH, Ahn HS, Kim SY, Shin J, Seo SM, Hong SJ, Kim W, Park CG

doi: 10.1161/HYPERTENSIONAHA.125.25810

Heart, Artery and Coronary DiseasesTherapy and Intervention

Sirolimus-Eluting Balloon With Provisional Stenting Versus Systematic Drug-Eluting Stent Implantation to Treat De Novo Coronary Lesions: A Randomized, Open-Label, Noninferiority Trial

Circulation

Spaulding C, Krackhardt F, Bogaerts K, Abdelaal E, Alfonso F, Briguori C, Bruch L, Cruden N, Den Hartog AW, Garot P, Godin M, Hildick-Smith D, Johnson T, Ladwiniec A, Linke A, Maart CA, Mashayekhi K, Meier P, Meunier L, Morgan K, O'Kane P, Puymirat E, Rissanen TT, Sabaté M, Schmitz T, Toth GG, Trevelyan J, Wanczura P, Marcus W, Wykrzykowska JJ, Urban P, Eccleshall S, SELUTION DeNovo Investigators

doi: 10.1161/CIRCULATIONAHA.126.079033

Cardiovascular Risk and DiseasesFurther Publications

High-Dose vs Standard-Dose Influenza Vaccine and Cardiovascular Outcomes in Older Adults: A Prespecified Secondary Analysis of the DANFLU-2 Randomized Clinical Trial

JAMA Cardiol

Johansen ND, Modin D, Loiacono MM, Harris RC, Dufournet M, Larsen CS, Larsen L, Wiese L, Dalager-Pedersen M, Claggett BL, Janstrup KH, Bartholdy KV, Bernholm KF, Borchsenius JIH, Davidovski FS, Davodian LW, Dons M, Duus LS, Espersen C, Fussing FH, Jensen AMR, Landler NE, Langhoff ACF, Lassen MCH, Nielsen AB, Ottosen CI, Sengeløv M, Skaarup KG, Pareek M, Solomon SD, Landray MJ, Gislason GH, Køber L, Sivapalan P, Martel CJ, Jensen JUS, Biering-Sørensen T

doi: 10.1001/jamacardio.2025.3460

Further Publications

Comparative effectiveness of influenza vaccination dosing strategies for cardiovascular protection: a systematic review and network meta-analysis of randomised controlled trials

Am Heart J

Hon JJ, Aikawa T, Biering-Sørensen T, Crouch E, Iwagami M, Slipczuk L, Briasoulis A, Wiley J, Hosseini K, Bhatt DL, Kuno T

doi: 10.1016/j.ahj.2026.107591

Myocardial InfarctionFurther Publications

Low-Dose Rivaroxaban to Prevent Left Ventricular Thrombosis After Anterior Myocardial Infarction: The APERITIF Randomized Clinical Trial

JAMA Cardiol

Puymirat E, Soulat G, Lattuca B, Bouleti C, Delarche N, Roubille F, Cottin Y, Bression D, Combaret N, Gerbaud E, Lhermusier T, Biere L, Dubreuil O, Mousseaux E, Steg PG, Cayla G, Lemesle G, Silvain J, Dillinger JG, Georges JL, Ducrocq G, Genet T, Morelle JF, Montalescot G, Berard L, Rousseau A, Soen M, Simon T, Danchin N, APERITIF study investigators

doi: 10.1001/jamacardio.2026.0026

Heart Failure

Sacubitril/Valsartan vs Enalapril in Heart Failure Due to Chagas Disease: An Open-Label, Multicenter Randomized Clinical Trial

JAMA

Lopes RD, Bocchi EA, Echeverría LE, Demacq C, de Barros E Silva PGM, Barbosa LM, Damiani L, Sayyed S, Yoshida LAF, Furtado RHM, Morillo CA, Kevorkian R, Ramires F, Bahit MC, Magaña A, Chávez-Mendoza A, Miguel da Silva AH, Coelho da Silva A, Freitas AF Jr, Romano AA, Parneix A, Segura A, França CCB, Botta CE, de Barros E, Perna ER, Montenegro E, Quiroz Diaz FR, Feitosa-Filho GS, Severini GV, Molina I, Miranda JDSS, Sala J, Kerr Saraiva JF, Carbajales J, Maia LN, Santana Passos LC, Simões MV, Moreira MDCV, Nunes MCP, Hernandes ME, Hominal M, Zarandon RS, Leon de la Fuente R, Aras R, Bazan SGZ, Luiz da Silva T Jr, Madrini V, de Oliveira WA Jr, Saporito WF, Gimpelewicz C, McMurray JJV, Prevention and Reduction of Adverse Outcomes in Chagasic Heart Failure Trial Evaluation (PARACHUTE-HF) Investigators

doi: 10.1001/jama.2025.19808

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1-month versus 12-month dual antithrombotic therapy after percutaneous coronary intervention in patients with atrial fibrillation (OPTIMA-AF): a multicentre, open-label, hybrid non-inferiority and superiority, randomised, controlled trial

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