Rapid whole-blood immune profiling reveals heterogeneous HBV-specific T cell response patterns independent of clinical disease phases

Hepatitis

Clinical results of an HBV-specific T-cell receptor-T-cell therapy (SCG101) in patients with HBV-related hepatocellular carcinoma treated in an investigator-initiated, interventional trial

Gut

Wu X, Quan D, Li W, Wisskirchen K, Wu W, Zhou Y, Liu YP, Wan X, Wang X, Zhang X, Yang L, Zheng M, Zhang K, Protzer U, Du S, Qu X

doi: 10.1136/gutjnl-2025-335456

Celiac Disease

Blood-based T Cell Diagnosis of Celiac Disease

Gastroenterology

Moscatelli OG, Russell AK, Henneken LM, Fothergill L, Motyer A, Reid H, Rossjohn J, Bryant V, Anderson RP, Hardy MY, Tye-Din JA

doi: 10.1053/j.gastro.2025.05.022

COMMENTED

Gastrointestinal CancerInflammatory Bowel Disease

Blood-borne immune cells carry low biomass DNA remnants of microbes in patients with colorectal cancer or inflammatory bowel disease

★ 3 Recommended and commented by Prof. Dr Stephan Vavricka, Faculty Member

Gut Microbes

Morsy Y, Walberg Å, Wawrzyniak P, Hubeli B, Truscello L, Mamie C, Niechcial A, Gueguen E, Manzini R, Gottier C, Lang S, Scharl S, Blümel S, Biedermann L, Rogler G, Turina M, Ramser M, Petrowsky H, Arnold IC, Zeissig S, Zamboni N, Egli A, Niess JH, Hruz P, Knuth A, Fritsch R, Manz MG, Wawrzyniak M, Scharl M

doi: 10.1080/19490976.2025.2530157

RECOMMENDED

Inflammatory Bowel DiseaseFurther Publications

Smoking affects gut immune system of patients with inflammatory bowel diseases by modulating metabolomic profiles and mucosal microbiota

★ 1 Recommended by Prof. Dr Stephan Vavricka, Faculty Member

Gut

Miyauchi E, Taida T, Uchiyama K, Nakanishi Y, Kato T, Koido S, Sasaki N, Ohkusa T, Sato N, Ohno H

doi: 10.1136/gutjnl-2025-334922

Gastrointestinal Cancer

Unlocking novel T cell-based immunotherapy for hepatocellular carcinoma through neoantigen-driven T cell receptor isolation

Gut

Maravelia P, Yao H, Cai C, Nascimento Silva D, Fransson J, Nilsson OB, Lu YW, Micke P, Botling J, Gatto F, Rovesti G, Carlsten M, Sallberg M, Stål P, Jorns C, Buggert M, Pasetto A

doi: 10.1136/gutjnl-2024-334148

Further Publications

Extended Risankizumab Treatment in Patients With Crohn's Disease Who Did Not Achieve Clinical Response to Induction Treatment

Clin Gastroenterol Hepatol

Panaccione R, Ferrante M, Dotan I, Panés J, Hisamatsu T, Bossuyt P, Danese S, Song A, Kalabic J, Joshi N, Zambrano J, Zhang Y, Duan WR, Kligys K, Dubinsky MC, Lindsay JO, Vermeire S, Siegmund B, Irving PM, D'Haens G

doi: 10.1016/j.cgh.2024.12.023

Inflammatory Bowel Disease

Assessment and Reporting of Extraintestinal Manifestations and Fatigue in Phase 3 Inflammatory Bowel Disease Clinical Trials

J Crohns Colitis

Chhibba T, Sachdeva K, Ananthakrishnan AN

doi: 10.1093/ecco-jcc/jjaf009

Hepatology

Steatotic liver disease classification is dynamic, affecting clinical trial eligibility and subclass-specific treatments

Clin Gastroenterol Hepatol

Israelsen M, Thorhauge KH, Andersen P, Johansen S, Schnefeld HL, Bech KT, Hansen JK, Torp N, Jensen EL, Hansen ED, Spedtsberg IZ, Villesen IF, Hansen CD, Hansen T, Lindvig KP, Thiele M, Krag A

doi: 10.1016/j.cgh.2025.02.007