Left Atrial Appendage Closure versus Oral Anticoagulation for Stroke Prevention in Atrial Fibrillation: Long-Term Outcomes from Four Randomized Trials

Atrial Fibrillation

3-Year Clinical Outcomes Comparing the Amulet vs Watchman FLX for Left Atrial Appendage Closure in Patients With Atrial Fibrillation: Results From the SWISS-APERO Randomized Clinical Trial

J Am Coll Cardiol

Galea R, De Marco F, Aminian A, Meneveau N, Chalkou K, Anselme F, Gräni C, Franzone A, Vranckx P, Fischer U, Valgimigli M, Räber L

doi: 10.1016/j.jacc.2025.03.535

Atrial Fibrillation

Left atrial appendage occlusion versus NOACs in patients with atrial fibrillation: Rationale and design of the CATALYST Trial

Am Heart J

Reddy VY, Hylek E, Camm AJ, Halperin JL, Diener HC, Thaler D, Schmidt B, Hara H, Huisman MV, Price MJ, Lakkireddy D, Gage R, Zhao H, Jensen TP, Quintana M, Windecker S

doi: 10.1016/j.ahj.2026.107367

Atrial FibrillationThrombosis and Stroke

Long-Term Outcomes Following Left Atrial Appendage Occlusion in Medicare Beneficiaries: Outcomes From the National Cardiovascular Data Registry

J Am Heart Assoc

Higgins AY, Zimmerman S, Wang Y, Friedman DJ, Faridi KF, Price MJ, Reddy VY, Holmes DR Jr, Curtis JP, Freeman JV

doi: 10.1161/JAHA.124.039780

Atrial FibrillationTherapy and Intervention

Rationale and design of the Anticoagulant Therapy after Left Atrial Appendage Closure (ATLAAC) Trial

Am Heart J

Gosvig K, Goller J, Hansson NH, Brandes A, Modrau I, Rasmussen LF, Eskesen K, Jensen AKG, Belley-Côté E, Whitlock R, Riber LPS

doi: 10.1016/j.ahj.2025.04.015

Atrial FibrillationTherapy and Intervention

Left Atrial Appendage Closure in Patients Refusing Oral Anticoagulation: The LAAC-REFUSAL Study

J Am Heart Assoc

Galea R, Bini T, Korsholm K, Sedaghat A, Aminian A, Vij V, Perich Krsnik J, Chalkou K, Siontis G, Roten L, Nielsen-Kudsk JE, Räber L

doi: 10.1161/JAHA.124.040404

Atrial FibrillationThrombosis and Stroke

Collaboration on the optimal timing of anticoagulation after ischaemic stroke and atrial fibrillation: a systematic review and prospective individual participant data meta-analysis of randomised controlled trials (CATALYST)

Lancet

Dehbi HM, Fischer U, Åsberg S, Milling TJ, Abend S, Ahmed N, Branca M, Davis LA, Engelter ST, Freemantle N, Gattringer T, Ghukasyan Lakic T, Hijazi Z, James M, Koga M, Lawrence P, Lemmens R, Lip GYH, Massingham S, Nash PS, Ndoutoumou A, Norrving B, Salanti G, Sprigg N, Thomalla G, Vanniyasingam T, Wester P, Warach SJ, Oldgren J, Dawson J, Werring DJ

doi: 10.1016/S0140-6736(25)00439-8

Thrombosis and Stroke

Impact of Peridevice Leak on Clinical Outcomes After Left Atrial Appendage Closure: The OCEAN-LAAC Registry

J Am Heart Assoc

Saito T, Tsuruta H, Kajino A, Iwata J, Sakata S, Ryuzaki T, Sago M, Tanaka S, Chatani R, Hachinohe D, Naganuma T, Ohno Y, Tani T, Okamatsu H, Mizutani K, Watanabe Y, Izumo M, Saji M, Mizuno S, Ueno H, Kubo S, Shirai S, Nakashima M, Asami M, Yamamoto M, Ieda M, Hayashida K, OCEAN‐LAAC investigators

doi: 10.1161/JAHA.125.044422

Atrial Fibrillation

Hemorrhagic Stroke in Atrial Fibrillation: Trends in Incidence, Case Fatality, and Prior Oral Anticoagulation

J Am Heart Assoc

Tiili P, Lehto M, Halminen O, Haukka J, Lehtonen O, Linna M, Satopää J, Korja M, Niemelä M, Kinnunen J, Aro AL, Mustonen P, Hartikainen J, Airaksinen KEJ, Putaala J, FinACAF study group

doi: 10.1161/JAHA.124.040360

Thrombosis and Stroke

Ischemic outcomes after left atrial appendage closure following intracerebral hemorrhage: a retrospective inverse probability weighting analysis from the HANSE-LAAC registry

Clin Res Cardiol

Jurczyk D, Mezger M, Lemmer F, Fatum C, Gradaus R, Drochner-Brocks NK, Saraei R, Frerker C, Stiermaier T, Paitazoglou C, Eitel I

doi: 10.1007/s00392-025-02668-7

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3-Year Clinical Outcomes Comparing the Amulet vs Watchman FLX for Left Atrial Appendage Closure in Patients With Atrial Fibrillation: Results From the SWISS-APERO Randomized Clinical Trial

Left atrial appendage occlusion versus NOACs in patients with atrial fibrillation: Rationale and design of the CATALYST Trial

Long-Term Outcomes Following Left Atrial Appendage Occlusion in Medicare Beneficiaries: Outcomes From the National Cardiovascular Data Registry

Rationale and design of the Anticoagulant Therapy after Left Atrial Appendage Closure (ATLAAC) Trial

Left Atrial Appendage Closure in Patients Refusing Oral Anticoagulation: The LAAC-REFUSAL Study

Collaboration on the optimal timing of anticoagulation after ischaemic stroke and atrial fibrillation: a systematic review and prospective individual participant data meta-analysis of randomised controlled trials (CATALYST)

Impact of Peridevice Leak on Clinical Outcomes After Left Atrial Appendage Closure: The OCEAN-LAAC Registry

Hemorrhagic Stroke in Atrial Fibrillation: Trends in Incidence, Case Fatality, and Prior Oral Anticoagulation

Ischemic outcomes after left atrial appendage closure following intracerebral hemorrhage: a retrospective inverse probability weighting analysis from the HANSE-LAAC registry