Neutrophil transcriptomics in SLE reveals intrinsic disease signatures, shared ex vivo adaptation, and transcriptional reset after CAR T-cell therapy

Systemic Lupus Erythematosus

Differential molecular signatures in response to CD19-CAR T cell therapy compared with conventional pharmacotherapy in systemic lupus erythematosus

Ann Rheum Dis

Garantziotis P, Beretta L, Lindblom J, Moysidou GS, Nikolopoulos D, Grieshaber-Bouyer R, Hagen M, Bergmann C, Wirsching A, Bozec A, PRECISESADS Clinical Consortium, Schneider M, Barturen G, Bertsias G, Boumpas DT, Alarcón-Riquelme ME, Mackensen A, Schett G, Parodis I

doi: 10.1016/j.ard.2025.06.2132

AcnePsoriasis

Spatial transcriptomics maps early B-cell and T-cell activation in hidradenitis suppurativa

J Invest Dermatol

Lee J, Ham S, Lee J, Krueger JG, Lee YI, Kim J

doi: 10.1016/j.jid.2026.01.041

T Cells

BK Virus-Specific T Cell Response Associated with HLA Genotypes, RhD Status, and CMV or EBV Serostatus in Healthy Donors for Optimized Cell Therapy

J Clin Immunol

Mora-Buch R, Tomás-Marín M, Pasamar H, Enrich E, Peña-Gómez C, Rudilla F

doi: 10.1007/s10875-025-01901-2

Systemic Lupus Erythematosus

Multi-omic profiling reveals immune cell priming signature linked to lupus prognosis

Arthritis Rheumatol

Smith MA, Sinibaldi D, Rahman S, Chiang CC, Hansen AM, Henault J, Roca CP, Wang S, Zerrouki K, Filippi R, Groves C, Manna Z, Chu J, Davis M, Gupta S, Morehouse C, de Los Reyes M, Ettinger R, Kolbeck R, Kaplan MJ, Sanjuan MA, Siegel RM, Hasni SA, Casey KA

doi: 10.1002/art.70105

Psoriatic Arthritis

Clonal sharing of CD8+ T-cells links skin and joint inflammation in psoriatic arthritis

Arthritis Rheumatol

Durham LE, Humby F, Ng N, Laddach R, Gray EH, Ryan SE, Steel KJA, Ross R, Povoleri GAM, Nuamah R, Fung K, Kallayil AM, Dhami P, Kirkham BW, Taams LS

doi: 10.1002/art.43286

Juvenile Idiopathic ArthritisRheumatoid Arthritis

Functional and dysfunctional T regulatory cell states in human tissues in RA and other autoimmune arthritic diseases

bioRxiv

Koh B, Oz STG, Sato R, Nguyen HN, Dunlap G, Mahony C, Bolton C, Accelerating Medicines Partnership (AMP) RA/SLE Network, Wedderburn LR, Croft AP, Donlin L, Raychaudhuri S, Korsunsky I, Rao DA, Brenner MB

doi: 10.1101/2025.09.23.677874

Further Publications Rheumatology

FGL-1 Modulates Inter-Organ Communication by Controlling T Cell Homeostasis during the Onset of Sjögren's Disease

Arthritis Rheumatol

Otsuka K, Ushio A, Nagao R, Matsuzawa S, Arakaki R, Fukuta K, Mouri Y, Tsunematsu T, Ishimaru N

doi: 10.1002/art.43236

Psoriasis

Unrestrained MyD88 signaling in A20-deficient keratinocytes triggers T cell dependent Psoriatic Arthritis like disease

J Invest Dermatol

Tobias R, Kumar S, Liu J, Lenci N, Gharabi A, Stibor D, Advincula R, Achacoso P, Huang ZM, Bowman C, Ricardo-Gonzalez R, Nakamura MC, Liao W, Malynn BA, Ma A, Razani B

doi: 10.1016/j.jid.2025.03.043

Autoimmune Disease

Autoimmune associated HLAs and T cell autoantigens exhibit common patterns across several autoimmune diseases

J Autoimmun

Saksager AB, Hede FD, Barra C

doi: 10.1016/j.jaut.2025.103443

Related content

Differential molecular signatures in response to CD19-CAR T cell therapy compared with conventional pharmacotherapy in systemic lupus erythematosus

Spatial transcriptomics maps early B-cell and T-cell activation in hidradenitis suppurativa

BK Virus-Specific T Cell Response Associated with HLA Genotypes, RhD Status, and CMV or EBV Serostatus in Healthy Donors for Optimized Cell Therapy

Multi-omic profiling reveals immune cell priming signature linked to lupus prognosis

Clonal sharing of CD8+ T-cells links skin and joint inflammation in psoriatic arthritis

Functional and dysfunctional T regulatory cell states in human tissues in RA and other autoimmune arthritic diseases

FGL-1 Modulates Inter-Organ Communication by Controlling T Cell Homeostasis during the Onset of Sjögren's Disease

Unrestrained MyD88 signaling in A20-deficient keratinocytes triggers T cell dependent Psoriatic Arthritis like disease

Autoimmune associated HLAs and T cell autoantigens exhibit common patterns across several autoimmune diseases